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MSC Opera cruises

66 cruises sail aboard the MSC Opera, ranging from 3 to 14 nights. Prices start at $179. Most-visited destinations: Caribbean (24).

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Showing the first 24 of 66 sailings

  1. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Nov 16, 2026
    back Nov 19
    Length
    3 nights
    From La Romana, Dominican Republic
    Ports
    Catalina Island
    From$179per guestas of 1 hour ago
    View sailing
  2. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Nov 16, 2026
    back Nov 20
    Length
    4 nights
    From La Romana, Dominican Republic
    Ports
    Bridgetown · Catalina Island
    From$329per guestas of 1 hour ago
    View sailing
  3. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Thu, Nov 19, 2026
    back Dec 3
    Length
    14 nights
    From Bridgetown
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic +4 more
    From$1,369per guestas of 1 hour ago
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  4. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Fri, Nov 20, 2026
    back Dec 4
    Length
    14 nights
    From Fort De France
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic +4 more
    From$1,229per guestas of 1 hour ago
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  5. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Nov 23, 2026
    back Nov 30
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic · Catalina Island
    From$749per guestas of 1 hour ago
    View sailing
  6. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Nov 30, 2026
    back Dec 7
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    Road Town (Tortola), British Virgin Islands · Bridgetown · Catalina Island · Fort De France · Pointe-a-Pitre, Guadeloupe
    From$709per guestas of 2 months ago
    View sailing
  7. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Thu, Dec 3, 2026
    back Dec 17
    Length
    14 nights
    From Bridgetown
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts · La Romana, Dominican Republic +3 more
    From$1,459per guestas of 1 hour ago
    View sailing
  8. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Fri, Dec 4, 2026
    back Dec 18
    Length
    14 nights
    From Fort De France
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts · Bridgetown +3 more
    From$1,439per guestas of 1 hour ago
    View sailing
  9. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Dec 7, 2026
    back Dec 14
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Road Town (Tortola), British Virgin Islands · Catalina Island
    From$419per guestas of 3 months ago
    View sailing
  10. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Dec 14, 2026
    back Dec 21
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    Road Town (Tortola), British Virgin Islands · Bridgetown · Catalina Island · Fort De France · Pointe-a-Pitre, Guadeloupe
    From$559per guestas of 1 hour ago
    View sailing
  11. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Thu, Dec 17, 2026
    back Dec 31
    Length
    14 nights
    From Bridgetown
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic +4 more
    From$1,979per guestas of 1 hour ago
    View sailing
  12. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Fri, Dec 18, 2026
    back Jan 1
    Length
    14 nights
    From Fort De France
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic +4 more
    From$2,819per guestas of 1 hour ago
    View sailing
  13. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Thu, Dec 31, 2026
    back Jan 14
    Length
    14 nights
    From Bridgetown
    Ports
    St. John's · Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts +4 more
    From$2,279per guestas of 1 hour ago
    View sailing
  14. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Fri, Jan 1, 2027
    back Jan 15
    Length
    14 nights
    From Fort De France
    Ports
    St. John's · Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts +4 more
    From$1,469per guestas of 1 hour ago
    View sailing
  15. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Jan 4, 2027
    back Jan 11
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic · Catalina Island
    From$599per guestas of 1 month ago
    View sailing
  16. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Jan 11, 2027
    back Jan 18
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    St. John's · Virgin Gorda, Virgin Islands · Bridgetown · Catalina Island · Fort De France
    From$629per guestas of 1 hour ago
    View sailing
  17. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Jan 11, 2027
    back Jan 25
    Length
    14 nights
    From La Romana, Dominican Republic
    Ports
    St. John's · Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Bridgetown +4 more
    From$1,390per guestas of 1 hour ago
    View sailing
  18. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Thu, Jan 14, 2027
    back Jan 28
    Length
    14 nights
    From Bridgetown
    Ports
    St. John's · Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic +3 more
    From$1,399per guestas of 1 hour ago
    View sailing
  19. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Fri, Jan 15, 2027
    back Jan 29
    Length
    14 nights
    From Fort De France
    Ports
    St. John's · Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic +3 more
    From$1,549per guestas of 1 hour ago
    View sailing
  20. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Jan 18, 2027
    back Jan 25
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Samana Bay, Dominican Republic · Catalina Island
    From$589per guestas of 1 hour ago
    View sailing
  21. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Jan 18, 2027
    back Feb 1
    Length
    14 nights
    From La Romana, Dominican Republic
    Ports
    Philipsburg, St. Maarten · St. John's · Virgin Gorda, Virgin Islands · Basseterre, St. Kitts · Road Town (Tortola), British Virgin Islands +5 more
    From$1,390per guestas of 1 hour ago
    View sailing
  22. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Jan 25, 2027
    back Feb 1
    Length
    7 nights
    From La Romana, Dominican Republic
    Ports
    St. John's · Road Town (Tortola), British Virgin Islands · Bridgetown · Catalina Island · Fort De France
    From$467per guestas of 1 month ago
    View sailing
  23. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Mon, Jan 25, 2027
    back Feb 8
    Length
    14 nights
    From La Romana, Dominican Republic
    Ports
    St. John's · Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts +4 more
    From$1,350per guestas of 1 hour ago
    View sailing
  24. CaribbeanMSC Cruises

    Southern Caribbean

    MSC Opera

    Departure
    Thu, Jan 28, 2027
    back Feb 11
    Length
    14 nights
    From Bridgetown
    Ports
    St. John's · Philipsburg, St. Maarten · Virgin Gorda, Virgin Islands · Road Town (Tortola), British Virgin Islands · Basseterre, St. Kitts +3 more
    From$1,469per guestas of 1 hour ago
    View sailing
See all 66 sailings

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