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South America cruises

257 cruises head to South America, ranging from 3 to 33 nights. Prices start at $369. Most-visited destinations: South America (24).

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Showing the first 24 of 257 sailings

  1. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Nov 14, 2026
    back Nov 21
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +10 more
    Pricing not availableCheck cruise line for live ratesas of 2 days ago
    View sailing
  2. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Mon, Nov 16, 2026
    back Nov 20
    Length
    4 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Ilha Grande, Brazil · Ilhabela, Brazil
    From$487per guestas of 1 hour ago
    View sailing
  3. South AmericaPrincess Cruises

    Brazilian Adventure

    Majestic Princess

    Departure
    Thu, Nov 19, 2026
    back Dec 7
    Length
    18 nights
    From Ft. Lauderdale, Florida
    Ports
    St. Maarten · St. Lucia · Barbados · Fortaleza, Brazil · Rio de Janeiro, Brazil +2 more
    From$1,659per guestas of 3 hours ago
    View sailing
  4. South AmericaPrincess Cruises

    Brazilian & Cape Horn Grand Adventure

    Majestic Princess

    Departure
    Thu, Nov 19, 2026
    back Dec 22
    Length
    33 nights
    From Ft. Lauderdale, Florida
    Ports
    St. Maarten · St. Lucia · Barbados · Fortaleza, Brazil · Rio de Janeiro, Brazil +12 more
    From$3,671per guestas of 8 days ago
    View sailing
  5. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Nov 21, 2026
    back Nov 28
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +8 more
    Pricing not availableCheck cruise line for live ratesas of 2 days ago
    View sailing
  6. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Mon, Nov 23, 2026
    back Nov 26
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$369per guestas of 1 hour ago
    View sailing
  7. South AmericaMSC Cruises

    South America

    MSC Virtuosa

    Departure
    Sat, Nov 28, 2026
    back Dec 2
    Length
    4 nights
    From Salvador, Brazil
    Ports
    Rio de Janeiro, Brazil
    From$488per guestas of 3 months ago
    View sailing
  8. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Nov 28, 2026
    back Dec 5
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +10 more
    Pricing not availableCheck cruise line for live ratesas of 2 days ago
    View sailing
  9. South AmericaMSC Cruises

    South America

    MSC Seaview

    Departure
    Sun, Nov 29, 2026
    back Dec 2
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$529per guestas of 1 hour ago
    View sailing
  10. South AmericaMSC Cruises

    South America

    MSC Divina

    Departure
    Sun, Nov 29, 2026
    back Dec 3
    Length
    4 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Ilha Grande, Brazil · Buzios, Brazil
    From$559per guestas of 1 hour ago
    View sailing
  11. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Mon, Nov 30, 2026
    back Dec 3
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$369per guestas of 1 hour ago
    View sailing
  12. South AmericaMSC Cruises

    South America

    MSC Virtuosa

    Departure
    Wed, Dec 2, 2026
    back Dec 5
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$429per guestas of 1 hour ago
    View sailing
  13. South AmericaMSC Cruises

    South America

    MSC Seaview

    Departure
    Wed, Dec 2, 2026
    back Dec 5
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Balneario Camboriu, Brazil
    From$529per guestas of 1 hour ago
    View sailing
  14. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Thu, Dec 3, 2026
    back Dec 6
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$369per guestas of 1 hour ago
    View sailing
  15. South AmericaMSC Cruises

    South America

    MSC Splendida

    Departure
    Thu, Dec 3, 2026
    back Dec 6
    Length
    3 nights
    From Buenos Aires, Argentina
    From$569per guestas of 1 month ago
    View sailing
  16. South AmericaMSC Cruises

    South America

    MSC Splendida

    Departure
    Thu, Dec 3, 2026
    back Dec 11
    Length
    8 nights
    From Buenos Aires, Argentina
    Ports
    Balneario Camboriu, Brazil · Rio de Janeiro, Brazil · Punta Del Este · Ilhabela, Brazil
    From$1,716per guestas of 1 hour ago
    View sailing
  17. South AmericaMSC Cruises

    South America

    MSC Virtuosa

    Departure
    Sat, Dec 5, 2026
    back Dec 8
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$485per guestas of 1 hour ago
    View sailing
  18. South AmericaMSC Cruises

    South America

    MSC Virtuosa

    Departure
    Sat, Dec 5, 2026
    back Dec 9
    Length
    4 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Salvador, Brazil · Buzios, Brazil
    From$629per guestas of 1 hour ago
    View sailing
  19. South AmericaMSC Cruises

    South America

    MSC Seaview

    Departure
    Sat, Dec 5, 2026
    back Dec 10
    Length
    5 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Balneario Camboriu, Brazil · Montevideo · Punta Del Este
    From$692per guestas of 1 month ago
    View sailing
  20. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Dec 5, 2026
    back Dec 12
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +8 more
    From$11,730per guestas of 2 days ago
    View sailing
  21. South AmericaMSC Cruises

    South America

    MSC Seaview

    Departure
    Sat, Dec 5, 2026
    back Dec 13
    Length
    8 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buenos Aires, Argentina · Balneario Camboriu, Brazil · Montevideo · Punta Del Este
    From$1,040per guestas of 1 hour ago
    View sailing
  22. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Sun, Dec 6, 2026
    back Dec 10
    Length
    4 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Ilha Grande, Brazil · Buzios, Brazil
    From$486per guestas of 1 hour ago
    View sailing
  23. South AmericaMSC Cruises

    South America

    MSC Seaview

    Departure
    Sun, Dec 6, 2026
    back Dec 14
    Length
    8 nights
    From Balneario Camboriu, Brazil
    Ports
    Buenos Aires, Argentina · Montevideo · Santos (Sao Paulo), Brazil · Punta Del Este
    From$1,029per guestas of 1 hour ago
    View sailing
  24. South AmericaMSC Cruises

    South America

    MSC Splendida

    Departure
    Sun, Dec 6, 2026
    back Dec 14
    Length
    8 nights
    From Rio de Janeiro, Brazil
    Ports
    Buenos Aires, Argentina · Balneario Camboriu, Brazil · Punta Del Este · Ilhabela, Brazil
    From$1,012per guestas of 1 hour ago
    View sailing
See all 257 sailings

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Cruise lines sailing South America

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