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South America cruises

214 cruises head to South America, ranging from 3 to 33 nights. Prices start at $369. Most-visited destinations: South America (24).

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Showing the first 24 of 214 sailings

  1. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Aug 29, 2026
    back Sep 5
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +9 more
    From$11,520per guestas of 6 hours ago
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  2. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Aug 29, 2026
    back Sep 12
    Length
    14 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +24 more
    Pricing not availableCheck cruise line for live ratesas of 6 hours ago
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  3. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Sep 5, 2026
    back Sep 12
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +9 more
    Pricing not availableCheck cruise line for live ratesas of 6 hours ago
    View sailing
  4. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Sep 12, 2026
    back Sep 19
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +8 more
    Pricing not availableCheck cruise line for live ratesas of 6 hours ago
    View sailing
  5. South AmericaSilversea Cruises

    Unknown Port to Unknown Port

    Silver Origin

    Departure
    Sat, Sep 19, 2026
    back Sep 26
    Length
    7 nights
    From Unknown Port
    Ports
    Unknown Port · Unknown Port · Unknown Port · Unknown Port · Unknown Port +11 more
    From$10,780per guestas of 6 hours ago
    View sailing
  6. South AmericaViking Ocean Cruises

    Southern Atlantic Crossing

    Viking Ocean Fleet

    Departure
    Sun, Nov 1, 2026
    back Nov 22
    Length
    21 nights
    From Barcelona (Tarragona), Spain
    Ports
    Barcelona (Tarragona), Spain · Granada (Málaga) · Casablanca · São Vicente Island (Mindelo) · Recife, Brazil +3 more
    From$4,999per guestas of 6 hours ago
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  7. South AmericaMSC Cruises

    South America

    MSC Divina

    Departure
    Thu, Nov 12, 2026
    back Nov 16
    Length
    4 nights
    From Salvador, Brazil
    Ports
    Rio de Janeiro, Brazil
    From$396per guestas of 28 days ago
    View sailing
  8. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Mon, Nov 16, 2026
    back Nov 20
    Length
    4 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Ilha Grande, Brazil · Ilhabela, Brazil
    From$537per guestas of 8 hours ago
    View sailing
  9. South AmericaHolland America Line

    16-DAY INCA & PANAMA CANAL DISCOVERY: LIMA OVERNIGHT

    Oosterdam

    Departure
    Wed, Nov 18, 2026
    back Dec 4
    Length
    16 nights
    From Fort Lauderdale
    From$1,808per guestas of 9 hours ago
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  10. South AmericaPrincess Cruises

    Brazilian Adventure

    Majestic Princess

    Departure
    Thu, Nov 19, 2026
    back Dec 7
    Length
    18 nights
    From Ft. Lauderdale, Florida
    Ports
    St. Maarten · St. Lucia · Barbados · Fortaleza, Brazil · Rio de Janeiro, Brazil +2 more
    From$2,059per guestas of 9 hours ago
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  11. South AmericaPrincess Cruises

    Brazilian & Cape Horn Grand Adventure

    Majestic Princess

    Departure
    Thu, Nov 19, 2026
    back Dec 22
    Length
    33 nights
    From Ft. Lauderdale, Florida
    Ports
    St. Maarten · St. Lucia · Barbados · Fortaleza, Brazil · Rio de Janeiro, Brazil +12 more
    From$4,031per guestas of 9 hours ago
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  12. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Fri, Nov 20, 2026
    back Nov 23
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$504per guestas of 2 months ago
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  13. South AmericaHolland America Line

    30-DAY LEGENDARY AMAZON EXPLORER

    Volendam

    Departure
    Sun, Nov 22, 2026
    back Dec 22
    Length
    30 nights
    From New York (Cape Liberty), New Jersey
    From$4,084per guestas of 9 hours ago
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  14. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Mon, Nov 23, 2026
    back Nov 26
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$369per guestas of 8 hours ago
    View sailing
  15. South AmericaHolland America Line

    27-DAY LEGENDARY AMAZON EXPLORER

    Volendam

    Departure
    Wed, Nov 25, 2026
    back Dec 22
    Length
    27 nights
    From Fort Lauderdale
    From$3,599per guestas of 9 hours ago
    View sailing
  16. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Thu, Nov 26, 2026
    back Nov 30
    Length
    4 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Ilha Grande, Brazil · Buzios, Brazil
    From$487per guestas of 2 months ago
    View sailing
  17. South AmericaMSC Cruises

    South America

    MSC Virtuosa

    Departure
    Sat, Nov 28, 2026
    back Dec 2
    Length
    4 nights
    From Salvador, Brazil
    Ports
    Rio de Janeiro, Brazil
    From$488per guestas of 6 days ago
    View sailing
  18. South AmericaMSC Cruises

    South America

    MSC Seaview

    Departure
    Sun, Nov 29, 2026
    back Dec 2
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$529per guestas of 8 hours ago
    View sailing
  19. South AmericaMSC Cruises

    South America

    MSC Divina

    Departure
    Sun, Nov 29, 2026
    back Dec 3
    Length
    4 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Ilha Grande, Brazil · Buzios, Brazil
    From$559per guestas of 8 hours ago
    View sailing
  20. South AmericaMSC Cruises

    South America

    MSC Splendida

    Departure
    Sun, Nov 29, 2026
    back Dec 6
    Length
    7 nights
    From Rio de Janeiro, Brazil
    Ports
    Buenos Aires, Argentina · Montevideo
    From$1,297per guestas of 1 month ago
    View sailing
  21. South AmericaMSC Cruises

    South America

    MSC Musica

    Departure
    Mon, Nov 30, 2026
    back Dec 3
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$369per guestas of 8 hours ago
    View sailing
  22. South AmericaViking Ocean Cruises

    South America & the Chilean Fjords

    Viking Ocean Fleet

    Departure
    Tue, Dec 1, 2026
    back Dec 18
    Length
    17 nights
    From Buenos Aires, Argentina
    Ports
    Buenos Aires, Argentina · Montevideo · Puerto Madryn · Port Stanley · Ushuaia +3 more
    From$7,999per guestas of 6 hours ago
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  23. South AmericaViking Ocean Cruises

    NEW! From the Caribbean to the Amazon

    Viking Ocean Fleet

    Departure
    Tue, Dec 1, 2026
    back Dec 22
    Length
    21 nights
    From San Juan
    Ports
    San Juan · Bridgetown · Îles du Salut · Santarém · Parintins +7 more
    From$11,499per guestas of 6 hours ago
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  24. South AmericaMSC Cruises

    South America

    MSC Virtuosa

    Departure
    Wed, Dec 2, 2026
    back Dec 5
    Length
    3 nights
    From Santos (Sao Paulo), Brazil
    Ports
    Buzios, Brazil
    From$429per guestas of 8 hours ago
    View sailing
See all 214 sailings

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