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Panama Canal cruises

142 cruises head to Panama Canal, ranging from 8 to 23 nights. Prices start at $649. Most-visited destinations: Panama Canal (24).

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Showing the first 24 of 142 sailings

  1. Panama CanalCelebrity Cruises

    Panama Canal & Southern Caribbean

    Celebrity Ascent

    Departure
    Mon, Nov 23, 2026
    back Dec 4
    Length
    11 nights
    From Fort Lauderdale
    Ports
    Cartagena · Panama Canal (Cruising) · Oranjestad · Willemstad · Kralendijk
    From$2,198per guestas of 3 hours ago
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  2. Panama CanalPrincess Cruises

    Panama Canal with Costa Rica & Caribbean

    Caribbean Princess

    Departure
    Mon, Nov 23, 2026
    back Dec 5
    Length
    12 nights
    From Ft. Lauderdale, Florida
    Ports
    Aruba · Cartagena, Spain · Panama Canal Partial Transit New Locks · Colon · Limon, Costa Rica +1 more
    From$649per guestas of 3 hours ago
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  3. Panama CanalCarnival Cruise Line

    14-Day Caribbean & Panama from New Orleans, LA

    Carnival Liberty

    Departure
    Sun, Nov 29, 2026
    back Dec 13
    Length
    14 nights
    From New Orleans, LA
    Ports
    Montego Bay · Aruba · Curaçao · Cartagena, Spain · Colón, Panama +1 more
    From$976per guestas of 3 hours ago
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  4. Panama CanalPrincess Cruises

    Panama Canal - Ocean to Ocean

    Crown Princess

    Departure
    Thu, Dec 3, 2026
    back Dec 19
    Length
    16 nights
    From Los Angeles, California
    Ports
    Puerto Vallarta · Huatulco, Mexico · Puerto Chiapas, Mexico · Puntarenas, Costa Rica · Fuerte Amador, Panama (for Panama City) +2 more
    From$1,109per guestas of 3 hours ago
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  5. Panama CanalPrincess Cruises

    Panama Canal with Costa Rica & Caribbean

    Caribbean Princess

    Departure
    Sat, Dec 5, 2026
    back Dec 17
    Length
    12 nights
    From Ft. Lauderdale, Florida
    Ports
    Grand Cayman, Cayman Islands · Falmouth, Jamaica · Cartagena, Spain · Panama Canal Partial Transit New Locks · Colon +2 more
    From$669per guestas of 3 hours ago
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  6. Panama CanalCarnival Cruise Line

    10-Day Caribbean & Panama from Galveston, TX

    Carnival Miracle

    Departure
    Mon, Dec 7, 2026
    back Dec 17
    Length
    10 nights
    From Galveston, TX
    Ports
    Cozumel · Limon, Costa Rica · Colón, Panama
    From$650per guestas of 3 hours ago
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  7. Panama CanalPrincess Cruises

    Panama Canal - Ocean to Ocean Holiday

    Island Princess

    Departure
    Sat, Dec 12, 2026
    back Dec 28
    Length
    16 nights
    From Ft. Lauderdale, Florida
    Ports
    Aruba · Panama Canal Full Transit Historic Locks · Fuerte Amador, Panama (for Panama City) · Puntarenas, Costa Rica · Puerto Chiapas, Mexico +2 more
    From$1,169per guestas of 11 days ago
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  8. Panama CanalPrincess Cruises

    Panama Canal with Costa Rica & Caribbean Holiday

    Caribbean Princess

    Departure
    Thu, Dec 17, 2026
    back Dec 29
    Length
    12 nights
    From Ft. Lauderdale, Florida
    Ports
    Aruba · Cartagena, Spain · Panama Canal Partial Transit New Locks · Colon · Limon, Costa Rica +1 more
    From$1,093per guestas of 2 months ago
    View sailing
  9. Panama CanalPrincess Cruises

    Panama Canal - Ocean to Ocean Holiday

    Island Princess

    Departure
    Mon, Dec 28, 2026
    back Jan 13
    Length
    16 nights
    From Los Angeles, California
    Ports
    Puerto Vallarta · Huatulco, Mexico · Puerto Chiapas, Mexico · Puntarenas, Costa Rica · Fuerte Amador, Panama (for Panama City) +2 more
    From$1,959per guestas of 20 days ago
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  10. Panama CanalPrincess Cruises

    Panama Canal with Costa Rica & Caribbean Holiday

    Caribbean Princess

    Departure
    Tue, Dec 29, 2026
    back Jan 10
    Length
    12 nights
    From Ft. Lauderdale, Florida
    Ports
    Aruba · Cartagena, Spain · Panama Canal Partial Transit New Locks · Colon · Limon, Costa Rica +1 more
    From$1,233per guestas of 3 months ago
    View sailing
  11. Panama CanalHolland America Line

    14-DAY PANAMA CANAL

    Zuiderdam

    Departure
    Sat, Jan 2, 2027
    back Jan 16
    Length
    14 nights
    From Miami
    From$1,645per guestas of 2 hours ago
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  12. Panama CanalPrincess Cruises

    Panama Canal - Ocean to Ocean

    Coral Princess

    Departure
    Wed, Jan 6, 2027
    back Jan 21
    Length
    15 nights
    From Ft. Lauderdale, Florida
    Ports
    Cartagena, Spain · Panama Canal Full Transit Historic Locks · Fuerte Amador, Panama (for Panama City) · Puntarenas, Costa Rica · Puerto Chiapas, Mexico +2 more
    From$1,792per guestas of 3 months ago
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  13. Panama CanalPrincess Cruises

    Panama Canal - Ocean to Ocean

    Coral Princess

    Departure
    Wed, Jan 6, 2027
    back Jan 29
    Length
    23 nights
    From Ft. Lauderdale, Florida
    Ports
    Cartagena, Spain · Panama Canal Full Transit Historic Locks · Fuerte Amador, Panama (for Panama City) · Puntarenas, Costa Rica · Puerto Chiapas, Mexico +5 more
    From$3,257per guestas of 18 days ago
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  14. Panama CanalPrincess Cruises

    Panama Canal with Costa Rica & Caribbean

    Caribbean Princess

    Departure
    Sun, Jan 10, 2027
    back Jan 22
    Length
    12 nights
    From Ft. Lauderdale, Florida
    Ports
    Curacao · Cartagena, Spain · Panama Canal Partial Transit New Locks · Colon · Limon, Costa Rica +1 more
    From$1,149per guestas of 3 months ago
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  15. Panama CanalPrincess Cruises

    Panama Canal - Ocean to Ocean

    Island Princess

    Departure
    Wed, Jan 13, 2027
    back Jan 29
    Length
    16 nights
    From Ft. Lauderdale, Florida
    Ports
    Aruba · Panama Canal Full Transit Historic Locks · Fuerte Amador, Panama (for Panama City) · Puntarenas, Costa Rica · Puerto Chiapas, Mexico +2 more
    From$1,799per guestas of 3 hours ago
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  16. Panama CanalCarnival Cruise Line

    8-Day Caribbean & Panama from Tampa, FL

    Carnival Legend

    Departure
    Sat, Jan 16, 2027
    back Jan 24
    Length
    8 nights
    From Tampa, FL
    Ports
    Limon, Costa Rica · Colón, Panama
    From$1,064per guestas of 3 hours ago
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  17. Panama CanalHolland America Line

    12-DAY PANAMA CANAL DISCOVERY: COSTA RICA & GREATER ANTILLES

    Nieuw Amsterdam

    Departure
    Sun, Jan 17, 2027
    back Jan 29
    Length
    12 nights
    From Fort Lauderdale
    From$1,844per guestas of 2 hours ago
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  18. Panama CanalCarnival Cruise Line

    10-Day Caribbean & Panama from Galveston, TX

    Carnival Miracle

    Departure
    Mon, Jan 18, 2027
    back Jan 28
    Length
    10 nights
    From Galveston, TX
    Ports
    Cozumel · Limon, Costa Rica · Colón, Panama
    From$1,021per guestas of 3 hours ago
    View sailing
  19. Panama CanalPrincess Cruises

    Panama Canal with Costa Rica & Caribbean

    Caribbean Princess

    Departure
    Fri, Jan 22, 2027
    back Feb 3
    Length
    12 nights
    From Ft. Lauderdale, Florida
    Ports
    Aruba · Cartagena, Spain · Panama Canal Partial Transit New Locks · Colon · Limon, Costa Rica +1 more
    From$1,210per guestas of 3 months ago
    View sailing
  20. Panama CanalPrincess Cruises

    Panama Canal - Ocean to Ocean

    Island Princess

    Departure
    Fri, Jan 29, 2027
    back Feb 14
    Length
    16 nights
    From San Diego
    Ports
    Puerto Vallarta · Huatulco, Mexico · Puerto Chiapas, Mexico · Puntarenas, Costa Rica · Fuerte Amador, Panama (for Panama City) +2 more
    From$1,919per guestas of 14 days ago
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  21. Panama CanalHolland America Line

    21-DAY EASTERN CARIBBEAN & PANAMA CANAL: U.S. VIRGIN ISLANDS

    Nieuw Amsterdam

    Departure
    Fri, Jan 29, 2027
    back Feb 19
    Length
    21 nights
    From Fort Lauderdale
    From$2,308per guestas of 2 hours ago
    View sailing
  22. Panama CanalHolland America Line

    15-DAY PANAMA CANAL

    Zuiderdam

    Departure
    Sat, Jan 30, 2027
    back Feb 14
    Length
    15 nights
    From San Diego
    From$1,983per guestas of 1 day ago
    View sailing
  23. Panama CanalCarnival Cruise Line

    13-Day Caribbean & Panama from Tampa, FL

    Carnival Legend

    Departure
    Sun, Jan 31, 2027
    back Feb 13
    Length
    13 nights
    From Tampa, FL
    Ports
    Grand Cayman, Cayman Islands · Limon, Costa Rica · Colón, Panama · Aruba · Curaçao
    From$1,322per guestas of 3 hours ago
    View sailing
  24. Panama CanalPrincess Cruises

    Panama Canal with Costa Rica & Caribbean

    Caribbean Princess

    Departure
    Wed, Feb 3, 2027
    back Feb 15
    Length
    12 nights
    From Ft. Lauderdale, Florida
    Ports
    Aruba · Cartagena, Spain · Panama Canal Partial Transit New Locks · Colon · Limon, Costa Rica +1 more
    From$1,124per guestas of 2 months ago
    View sailing
See all 142 sailings

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